Peer-reviewed veterinary case report
Characterization of monoclonal antibodies directed against the canine distemper virus nucleocapsid protein.
- Journal:
- Comparative immunology, microbiology and infectious diseases
- Year:
- 2006
- Authors:
- Masuda, Munemitsu et al.
- Affiliation:
- Department of Biochemistry · Japan
- Species:
- dog
Abstract
We have established four monoclonal antibodies (MAbs) against the nucleocapsid protein (NP) of canine distemper virus (CDV). A competitive binding assay has revealed that the MAbs are directed against two antigenic domains. An immunofluorescence assay using a series of deletion clones of the NP and an immunoprecipitation assay using the NP have revealed that two of the MAbs recognize the C-terminal region of the NP while the other two recognize the tertiary structure of the N-terminal domain. These MAbs reacted with all eight strains of CDV used in this study, but showed different reactivities against measles virus and rinderpest virus.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/16697903/