Peer-reviewed veterinary case report
Characterization of mouse model-derived osteosarcoma (OS) cells in vitro and in vivo.
- Journal:
- Methods in molecular biology (Clifton, N.J.)
- Year:
- 2015
- Authors:
- Uluçkan, Özge et al.
- Affiliation:
- BBVA Foundation-CNIO Cancer Cell Biology Program · Spain
Abstract
Osteosarcoma (OS) is the most common primary tumor of bone with a high incidence in children. Treatment options for OS are limited, and once metastasized, the prognosis is very poor. Genetically engineered mouse models (GEMMs) are valuable tools to understand the mechanisms of tumorigenesis and to test possible therapies. In this chapter, we summarize the methods related to the isolation, characterization, and transplantation of OS cells obtained from GEMMs.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/25636475/