Peer-reviewed veterinary case report
Mucin gene changes in inflammatory colon polyps in miniature
By Nagata, Noriyuki et al.Ā·Published in The Journal of veterinary medical scienceĀ·2022Ā·Veterinary Teaching Hospital, JapanĀ·View original on PubMed ā
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Original publication title: Characterization of mucin gene expression and goblet cell proportion in inflammatory colorectal polyps in miniature dachshunds.
- Species:
- dog
Plain-English summary
A group of miniature dachshunds with inflammatory colorectal polyps (ICRPs) showed changes in certain mucus-producing cells in their intestines. These dogs had higher levels of a specific mucin gene (MUC5AC) compared to healthy dogs, indicating a possible link to their condition. While the number of goblet cells (which produce mucus) in the lower part of their intestines was lower in the affected dogs, the upper part showed no significant difference. Understanding these changes may help veterinarians better diagnose and treat ICRPs in dachshunds.
People also search for: miniature dachshund inflammatory bowel disease Ā· dog colorectal polyps symptoms Ā· dachshund mucus production issues
Abstract
Hyperplastic goblet cells and abundant mucus are significant characteristics of inflammatory colorectal polyps (ICRPs) in miniature dachshunds. In this study, selected mucin gene expressions and goblet cell proportions were evaluated in miniature dachshunds with ICRPs and in healthy dogs. Mucin 2 (MUC2) gene expression was not significantly different among the groups, whereas mucin 5AC (MUC5AC) gene expression was significantly higher in the polypoid lesions than in healthy colonic mucosa. Although the percentage of goblet cells in the upper crypt regions did not significantly differ between the groups, that in the lower crypt regions was significantly decreased in polypoid lesions. In conclusion, increased MUC5AC gene expression and goblet cell proportion changes may be associated with the pathogenesis of ICRPs.
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Search related cases āOriginal publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/35527018/