Peer-reviewed veterinary case report
Skin bacteria changes in dogs with mast cell tumors
By Zamarian, Valentina et al.·Published in Scientific reports·2020·Dipartimento Di Medicina Veterinaria, Italy·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Characterization of skin surface and dermal microbiota in dogs with mast cell tumor.
- Species:
- dog
Plain-English summary
A group of 11 dogs with mast cell tumors (a type of skin cancer) had their skin microbiota examined to see how it differed from healthy skin. The study found that the skin of dogs with tumors had fewer types of bacteria compared to the skin on the opposite side, which was healthy. Specifically, there was an increase in certain bacteria associated with the tumors. This suggests that changes in the skin's microbial community may be linked to the presence of mast cell tumors. More research is needed to understand how these changes affect the dog's immune response and overall health.
People also search for: dog mast cell tumor symptoms · skin cancer in dogs treatment · changes in dog skin bacteria
Abstract
The skin microbiota interacts with the host immune response to maintain the homeostasis. Changes in the skin microbiota are linked to the onset and the progression of several diseases, including tumors. We characterized the skin surface and dermal microbiota of 11 dogs affected by spontaneous mast cell tumor (MCT), using skin contralateral sites as intra-animal healthy controls. The microbial profile differed between healthy and tumor skin surfaces and dermis, demonstrating that the change in microbiota composition is related to the presence of MCT. The number of observed taxa between MCT and healthy skin surfaces was detected, showing a decrease in number and heterogeneity of taxa over the skin surface of MCT, at both inter- and intra-individual level. Preliminary data on bacterial population of MCT dermis, obtained only on three dogs, demonstrated an intra-individual reduction of taxa number when compared to the skin surface. Taxonomy reveals an increase of Firmicutes phylum and Corynebacteriaceae family in MCT skin surface when compared to the healthy contralateral. In conclusion, we demonstrate that microbial population of skin surface and dermis is related to mast cell tumor. Our study provides the basis for future investigations aiming to better define the interaction between mast cell tumors, microbiota and host immune response.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/32724217/