Peer-reviewed veterinary case report
Characterization of the cDNA Encoding alphaIIb and beta3 in normal horses and two horses with Glanzmann thrombasthenia.
- Journal:
- Veterinary pathology
- Year:
- 2006
- Authors:
- Christopherson, P W et al.
- Affiliation:
- Department of Pathobiology · United States
- Species:
- horse
Abstract
Glanzmann thrombasthenia (GT) is an inherited, intrinsic platelet defect characterized by a quantitative or qualitative change in the platelet glycoprotein complex IIb-IIIa (integrin alpha(IIb)beta3). The subunits are encoded by separate genes and both subunits must be expressed for a stable complex to form on the platelet surface; therefore, a defect in either gene can result in GT.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/16407493/