Peer-reviewed veterinary case report
Fecal virus types found in dogs with chronic gut disease
By Moreno, Paloma S et al.·Published in Veterinary microbiology·2018·Murdoch Children's Research Institute, Australia·View original on PubMed →
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Original publication title: Characterization of the fecal virome in dogs with chronic enteropathy.
- Species:
- dog
Plain-English summary
A group of dogs with chronic enteropathy (CE), which causes ongoing digestive issues, had their fecal samples tested for viruses. Researchers found that the fecal virome, or the collection of viruses in their poop, was different from that of healthy dogs. Specifically, dogs with CE had fewer types of viral families compared to healthy dogs, and one dog with CE tested positive for a specific virus called canine kobuvirus. This study highlights how the viral makeup in the feces of dogs with CE can differ significantly from healthy dogs, which may help in understanding their condition better.
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Abstract
The fecal virome has been investigated in humans and various animal species using next generation sequencing. However, limited information is available about the fecal virome of dogs with chronic enteropathy (CE). We aimed to characterize the canine fecal virome of dogs with CE and compare it with the virome of previously analyzed healthy dogs.A total of 16 adult dogs; 8 healthy dogs (data from a parallel study) and 8 dogs with CE had fecal samples assessed by viral shotgun sequencing. Fecal samples were subjected to enrichment of viral nucleic acids prior to sequencing and metagenomic analyses. Characterization of the complete genome of a canine kobuvirus was performed by Sanger sequencing. An additional 21 healthy dogs and 14 dogs with CE were further analyzed for the prevalence of canine kobuvirus.Three fecal samples from dogs with CE contained in total 3 eukaryotic viral families. In contrast, 4/8 fecal samples previously identified from healthy dogs, contained 5 eukaryotic viral families with 2 families exclusive to this group. Bacteriophages were identified in all fecal samples from CE and healthy dogs. Canine kobuvirus was identified in one dog with CE, by shotgun sequencing, and the complete genome was then characterized. This kobuvirus was classified within canine kobuvirus group, being similar to strains from Korea and China. The larger prevalence study did not detect additional samples positive for canine kobuvirus. The fecal virome of dogs with CE differs in number and type of viral families from healthy dogs. The first Australian canine kobuvirus sequence was identified and characterized from a dog with CE.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/29981706/