Peer-reviewed veterinary case report
Characterization of the L genome segment of an orthohantavirus isolated from Niviventer confucianus.
- Journal:
- Archives of virology
- Year:
- 2019
- Authors:
- Dai, Xiaoxia et al.
- Affiliation:
- School of Public Health · China
Abstract
We sequenced and analyzed the L segment of the RNA genome of Hantaan virus (HTNV) strain NC167. This segment is 6,533 nucleotides in length and contains a single open reading frame (ORF) of 6,456 nucleotides in the antigenome sense that encodes the viral RNA-dependent RNA polymerase, which is 2,153 amino acids long with a predicted molecular mass of 246 kDa. The 5' terminus of the viral RNA was found to contain the expected sequences that are conserved in orthohantaviruses. According to the phylogenetics and levels of sequence similarity, the L segment of HTNV NC167 is similar to but clearly distinct from the L segments of other orthohantaviruses.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/30350033/