Peer-reviewed veterinary case report
Characterizing the role of tissue-type plasminogen activator in a mouse model of Group A streptococcal infection.
- Journal:
- Microbes and infection
- Year:
- 2019
- Authors:
- Ly, Diane et al.
- Affiliation:
- Illawarra Health and Medical Research Institute and School of Chemistry and Molecular Bioscience · United Kingdom
- Species:
- rodent
Abstract
Plasmin(ogen) acquisition is critical for invasive disease initiation by Streptococcus pyogenes (GAS). Host urokinase plasminogen activator (uPA) plays a role in mediating plasminogen activation for GAS dissemination, however the contribution of tissue-type plasminogen activator (tPA) to GAS virulence is unknown. Using novel tPA-deficient ALBPLG1 mice, our study revealed no difference in mouse survival, bacterial dissemination or the pathology of GAS infection in the absence of tPA in AlbPLG1/tPAmice compared to AlbPLG1 mice. This study suggests that tPA has a limited role in this humanized model of GAS infection, further highlighting the importance of its counterpart uPA in GAS disease.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/31009808/