Peer-reviewed veterinary case report
Chemical modification of ovatodiolide revealed a promising amino-prodrug with improved pharmacokinetic profile.
- Journal:
- Chemical communications (Cambridge, England)
- Year:
- 2020
- Authors:
- Xiang, Junhong et al.
- Affiliation:
- College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research · China
Abstract
Stepwise modification of ovatodiolide revealed a prodrug, NMP-diepoxyovatodiolide, which can provide sustained release of an active compound, substantial metabolic stability and a unique accumulation profile in the liver. Besides, NMP-diepoxyovatodiolide demonstrated therapeutic benefits in an acute autoimmune hepatitis mouse model and a broad safety window. Therefore, NMP-diepoxyovatodiolide is a very promising candidate for further development of liver-related drugs.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/32856652/