Peer-reviewed veterinary case report
Stability of compounded ceftazidime in different solutions
By Snidow, McKenna et al.·Published in Veterinary dermatology·2025·Department of Clinical Sciences, United States·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Chemical Stability of Ceftazidime Compounded in Saline, Glycerin and Dexamethasone-SP Solutions Stored at -20°C, 4°C and 25°C Over a 60 Day Period.
- Species:
- dog
Plain-English summary
A dog with chronic ear infections caused by a tough-to-treat bacteria called Pseudomonas aeruginosa was treated with compounded ceftazidime solutions. Researchers tested how well these solutions held up when stored at different temperatures over 60 days. They found that the solutions stored in the freezer remained stable and effective for at least 60 days, while those kept in the fridge were only good for about 28 days. This means that using compounded ceftazidime can be a reliable option for treating stubborn ear infections in dogs, especially when stored properly.
People also search for: dog ear infection treatment · compounded ceftazidime for dogs · Pseudomonas ear infection in dogs
Abstract
BACKGROUND: Chronic cases of canine otitis externa (OE) often develop infections with Pseudomonas aeruginosa (PA). Given the organism's high level of resistance, veterinary surgeons often turn to compounded solutions. Limited data describing the stability and potency of compounded ceftazidime (CAZ) solutions are available, which may affect clinical outcome. HYPOTHESIS/OBJECTIVES: To evaluate the chemical stability of compounded glycerin (GLY) and dexamethasone sodium phosphate (DEX-SP) CAZ solutions in three different storage temperatures over a 60-day period. Based on previous evaluations, CAZ concentrations would decrease with increased temperature and time. MATERIALS AND METHODS: Ceftazidime was compounded at 10 mg/mL with 100 mL 0.9% sodium chloride (NA + CAZ), 100 mL glycerin +0.9% sodium chloride (GLY + CAZ) and 100 mL dexamethasone sodium phosphate +0.9% sodium chloride (DEX-SP + CAZ), stored at -20°C, 4°C and 25°C for 60 days. Mass spectrometry was used to analyse CAZ stability at specific time points (Day[D]0, D7, D14, D28, D60). RESULTS: Chemical stability of CAZ concentrations was affected by storage time, temperature and diluent. CAZ concentrations decreased over time with increased temperature; frozen CAZ concentrations remained stable over time for all solutions. CONCLUSIONS AND CLINICAL RELEVANCE: Compounded CAZ stability varies by diluent, storage temperature and storage duration. NA + CAZ and DEX-SP + CAZ solutions are stable for ≤ 28 days refrigerated and retain potency for ≥ 60 days if stored frozen. These solutions offer alternative options for treatment of PA OE.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/40686190/