Peer-reviewed veterinary case report
Chemoprevention by Prunella vulgaris L. extract of non-small cell lung cancer via promoting apoptosis and regulating the cell cycle.
- Journal:
- Asian Pacific journal of cancer prevention : APJCP
- Year:
- 2010
- Authors:
- Feng, Liang et al.
- Affiliation:
- Key Laboratory of Delivery Systems of Chinese Meteria Medica · China
Abstract
Chemoprevention is one feasible approach to decreasing morbidity and mortality of non-small cell lung cancer (NSCLC). The present study aimed to explore the mechanisms of chemoprevention of NSCLC by Prunella vulgaris L. (PV) using a PV extract of 60% ethanol (P-60). In an A/J mouse model benzo[a]pyrene induction of lung tumors was significantly reduced difference by P-60 group. In addition, P-60 was found to have the ability to regulate cell cycle and induce apoptosis in SPC-A-1 cells. Therefore, we propose that P-60 has potential as a lung cancer chemopreventive agent.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/21198292/