Peer-reviewed veterinary case report
Chimeric provirus of bovine leukemia virus/SMAD family member 3 in cattle with enzootic bovine leukosis.
- Journal:
- Archives of virology
- Year:
- 2024
- Authors:
- Nao, Naganori et al.
- Affiliation:
- International Institute for Zoonosis Control · Japan
Abstract
Bovine leukemia virus (BLV) is a member of the family Retroviridae that causes enzootic bovine leukemia (EBL). However, the association between BLV infection and EBL development remains unclear. In this study, we identified a BLV/SMAD3 chimeric provirus within CC2D2A intron 30 in monoclonal expanded malignant cells from a cow with EBL. The chimeric provirus harbored a spliced SMAD3 sequence composed of exons 3-9, encoding the short isoform protein, and the BLV-SMAD3 chimeric transcript was detectable in cattle with EBL. This is the first report of a BLV chimeric provirus that might be involved in EBL tumorigenesis.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/38366081/