Peer-reviewed veterinary case report
Cholesterol is not an essential source of nutrition for Mycobacterium tuberculosis during infection.
- Journal:
- Journal of bacteriology
- Year:
- 2011
- Authors:
- Yang, Xinxin et al.
- Affiliation:
- Department of Chemistry · United States
- Species:
- rodent
Abstract
Rv1106c (hsd; 3β-hydroxysteroid dehydrogenase) is required by Mycobacterium tuberculosis for growth on cholesterol as a sole carbon source, whereas Rv3409c is not. Mutation of Rv1106c does not reduce Mycobacterium tuberculosis growth in infected macrophages or guinea pigs. We conclude that cholesterol is not required as a nutritional source during infection.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/21257778/