Peer-reviewed veterinary case report
Choline treatment improves heart and breathing in dogs with endotoxin
By Kocaturk, Meric et al.·Published in Research in veterinary science·2021·Department of Internal Medicine·View original on PubMed →
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Original publication title: Choline or CDP-choline restores hypotension and improves myocardial and respiratory functions in dogs with experimentally - Induced endotoxic shock.
- Species:
- dog
Plain-English summary
A group of dogs experienced severe drops in blood pressure and breathing problems due to a condition called endotoxin shock, which can occur after infections. They were treated with either choline or CDP-choline, which are compounds that help improve heart and lung function. The results showed that both treatments significantly reduced the negative effects of endotoxin shock, leading to better blood pressure and respiratory rates compared to untreated dogs. This suggests that choline and CDP-choline could be helpful in managing similar cases in real-life situations.
People also search for: dog low blood pressure treatment · dog breathing problems endotoxin shock · choline for dogs heart function
Abstract
Endotoxin shock is associated with severe impairments in cardiovascular and respiratory functions. We showed previously that choline or cytidine-5'-diphosphocholine (CDP-choline) provides beneficial effects in experimental endotoxin shock in dogs. The objective of the present study was to determine the effects of choline or CDP-choline on endotoxin-induced cardiovascular and respiratory dysfunctions. Dogs were treated intravenously (i.v.) with saline or endotoxin (LPS, 0.1 mg/kg) 5 min before i.v. infusion of saline, choline (20 mg/kg) or CDP-choline (70 mg/kg). Blood pressure, cardiac rate, myocardial and left ventricular functions, respiratory rate, blood gases, serum electrolytes and cardiac injury markers were determined before and at 0.5-48 h after endotoxin. Plasma tumor necrosis factor alpha (TNF-α), high mobility group box-1 (HMGB1), catecholamine and nitric oxide (NO) levels were measured 2 h and 24 h after the treatments. Endotoxin caused immediate and sustained reductions in blood pressure, cardiac output, pOand pH; changes in left ventricular functions, structure and volume parameters; and elevations in heart rate, respiratory rate, pCO2 and serum electrolytes (Na, K, Cl, Ca and P). Endotoxin also resulted in elevations in blood levels of cardiac injury markers, TNF-α, HMGB1, catecholamine and NO. In choline- or CDP-choline-treated dogs, all endotoxin effects were much smaller in magnitude and shorter in duration than observed values in controls. These data show that treatment with choline or CDP-choline improves functions of cardiovascular and respiratory systems in experimental endotoxemia and suggest that they may be useful in treatment of endotoxin shock in clinical setting.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/34715589/