Peer-reviewed veterinary case report
Cholinergic axon length reduced by 300 meters in the brain of an Alzheimer mouse model.
- Journal:
- Neurobiology of aging
- Year:
- 2011
- Authors:
- Nikolajsen, Gitte Nykjær et al.
- Affiliation:
- Institute for Biomedicine
Abstract
Modern stereological techniques have been used to show that the total length of the cholinergic fibers in the cerebral cortex of the APPswe/PS1deltaE9 mouse is reduced by almost 300 meters at 18 months of age and has a nonlinear relationship to the amount of transgenetically-induced amyloidosis. These data provide rigorous quantitative morphological evidence that Alzheimer's-like amyloidosis affects the axons of the cholinergic enervation of the cerebral cortex.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/21752495/