Peer-reviewed veterinary case report
Lipid differences in healthy, obese, and hyperadrenocorticism dogs
By Jericó, Márcia Marques et al.·Published in Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·2009·Rua Joaquim Antunes, Brazil·View original on PubMed →
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Original publication title: Chromatographic analysis of lipid fractions in healthy dogs and dogs with obesity or hyperadrenocorticism.
- Species:
- dog
Plain-English summary
A group of dogs with obesity or a condition called hyperadrenocorticism (HAC) were studied to understand their fat levels compared to healthy dogs. The dogs with HAC had much higher levels of certain fats and cholesterol in their blood, which could put them at risk for other health issues. This research helps veterinarians tell the difference between just being overweight and having HAC, which is important for choosing the right treatment. If your dog is overweight or has been diagnosed with HAC, it's essential to discuss their diet and health risks with your vet.
People also search for: dog obesity treatment · hyperadrenocorticism in dogs · dog cholesterol levels · signs of Cushing's disease in dogs
Abstract
Obesity and endogenous hyperadrenocorticism (HAC) are common clinical conditions in veterinary practice, and both conditions have clinical and laboratory similarities, such as weight gain and dyslipidemia. The objective of the present study was to characterize and compare the lipid profiles and plasma lipoprotein fractions in healthy dogs (n = 10), in obese dogs (n = 10), and in dogs with HAC (n = 6). All of the dogs were client owned. The lipoproteins were separated by fast protein liquid chromatography, and the plasma concentrations of total cholesterol and total triacylglycerol (TAG) were determined by enzymatic methods. When compared with the healthy and obese groups, dogs with HAC had a significant increase (P < 0.01) in the total concentrations of TAGs and cholesterol (CHOL), with higher distribution in the very low-density lipoprotein (VLDL)-CHOL fractions. In addition, the distributions of the high-density lipoprotein (HDL)-CHOL and HDL-TAG fractions were significantly lower (P < 0.01) in dogs with HAC than in healthy dogs. Considering the animals in this study, it was determined that the dogs with HAC differed significantly from the healthy and obese dogs regarding the metabolism of CHOL and TAG, as well as their VLDL and HDL fractions. Similar laboratory findings could allow veterinarians to distinguish obese dogs from those with HAC. In addition, dogs with HAC may be at higher risk for developing metabolic and atherosclerotic complications.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/19286498/