Peer-reviewed veterinary case report
Chromosome instability in a calf with amelia of thoracic limbs.
- Journal:
- Veterinary pathology
- Year:
- 2006
- Authors:
- Szczerbal, I et al.
- Affiliation:
- Department of Genetics and Animal Breeding
Abstract
We report here on a case of a Holstein-Friesian male calf with the congenital total absence of thoracic limbs (amelia). Cytogenetic study showed a high rate of chromosome instability, represented by chromosome or chromatid breaks and gaps in 46% of the analyzed metaphase spreads. Moreover, 12% of the spreads appeared to be polypolid. The number of micronuclei also was significantly higher when compared to control animals. This paper discusses the association between chromosome instability and limb malformation.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/16966464/