Peer-reviewed veterinary case report
Chronic antagonism of the mineralocorticoid receptor ameliorates hypertension and end organ damage in a rodent model of salt-sensitive hypertension.
- Journal:
- Clinical and experimental hypertension (New York, N.Y. : 1993)
- Year:
- 2011
- Authors:
- Zhou, Xiaoyan et al.
- Affiliation:
- Department of Cardiovascular Diseases · United States
- Species:
- rodent
Abstract
We investigated the effects of chronic mineralocorticoid receptor blockade with eplerenone on the development and progression of hypertension and end organ damage in Dahl salt-sensitive rats. Eplerenone significantly attenuated the progressive rise in systolic blood pressure (SBP) (204 ± 3 vs. 179±3 mmHg, p < 0.05), reduced proteinuria (605.5 ± 29.6 vs. 479.7 ± 26.1 mg/24h, p < 0.05), improved injury scores of glomeruli, tubules, renal interstitium, and vasculature in Dahl salt-sensitive rats fed a high-salt diet. These results demonstrate that mineralocorticoid receptor antagonism provides target organ protection and attenuates the development of elevated blood pressure (BP) in a model of salt-sensitive hypertension.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/21950654/