Peer-reviewed veterinary case report
Chronic kidney disease and oxalate nephrosis in Ragdoll cats
By Heiene, Reidun et al.·Published in Journal of Feline Medicine and Surgery·2009·Department of Companion Animal Clinical Sciences, Norwegian School of Veterinary Science, PO Box 8146 Dep, N-0033 Oslo, Norway·View original on Crossref →
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Original publication title: Chronic kidney disease with three cases of oxalate-like nephrosis in Ragdoll cats
- Species:
- cat
Plain-English summary
Two Ragdoll cats in Norway were found dead due to kidney disease, which was linked to a condition called oxalate nephrosis. Their families showed signs of urinary tract issues, including a kitten that died from urethral gravel. Eleven related Ragdoll cats were tested for a genetic condition that can cause kidney problems, but none were found to have it. Five of these cats had kidney abnormalities on ultrasound, and one developed severe kidney disease months later. The exact cause of the kidney issues in this breed is still unclear.
People also search for: Ragdoll cat kidney disease symptoms · cat urinary tract problems · oxalate nephrosis in cats · kidney disease treatment for cats
Abstract
Two unrelated Ragdoll cat mothers in Norway were found dead from renal disease. The histopathology was consistent with oxalate nephrosis with chronic or acute-on-chronic underlying kidney disease. Both cats had offspring and relatives with signs of urinary tract disease, including a kitten dead with urethral gravel. Eleven living Ragdoll cats, including nine relatives of the dead cats and the male father of a litter with similarly affected animals, were tested for primary hyperoxaluria (PH) type 1 and 2 by urine oxalate and liver enzyme analysis. Renal ultrasound revealed abnormalities in five living cats. One of these was azotaemic at the time of examination and developed terminal kidney disease 9 months later. A diagnosis of PH was excluded in 11 cats tested. The inheritance and aetiological background of the renal disease present in the breed remains unresolved at this point in time.
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Search related cases →Original publication on Crossref: https://doi.org/10.1016/j.jfms.2008.11.003