Peer-reviewed veterinary case report
Chronic phencyclidine administration induces schizophrenia-like changes in N-acetylaspartate and N-acetylaspartylglutamate in rat brain.
- Journal:
- Schizophrenia research
- Year:
- 2005
- Authors:
- Reynolds, Lindsay M et al.
- Affiliation:
- Department of Biomedical Science · United Kingdom
- Species:
- rodent
Abstract
Administration of phencyclidine (PCP) to both humans and animals models the symptoms of schizophrenia. Brain concentrations of N-acetylaspartate (NAA) are reduced in this disease, reflecting neuronal dysfunction. This study investigates the effects in rats of a chronic intermittent regime of PCP on NAA and its precursor N-acetylaspartylglutamate (NAAG) in rat frontal and temporal cortex, hippocampus and striatum, determined by HPLC. We found significant PCP-induced deficits of NAA and NAAG only in the temporal cortex; NAAG was significantly elevated in the hippocampus. These changes closely reflect postmortem findings reported in schizophrenia.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/15653257/