Peer-reviewed veterinary case report
Ciclosporin 10 years on: indications and efficacy.
- Journal:
- The Veterinary record
- Year:
- 2014
- Authors:
- Forsythe, Peter & Paterson, Sue
- Affiliation:
- The Dermatology Referral Service · United Kingdom
- Species:
- dog
Plain-English summary
Ciclosporin is a medication that helps control the immune system and has been used in veterinary medicine for about 20 years. It works by preventing certain immune cells from becoming active, which is helpful for treating skin conditions in dogs, especially atopic dermatitis (a common allergic skin condition). Since 2003, it has been officially approved for this use, but it can also help with other skin issues like perianal fistulas, sebaceous adenitis, pododermatitis, chronic ear infections, and pemphigus foliaceus. The article discusses how the drug works, how it's processed in the body, and its effectiveness for these conditions. Overall, ciclosporin has been shown to be effective for managing various skin problems in dogs.
Abstract
Ciclosporin is a lipophilic cyclic polypeptide with powerful immunosuppressive and immunomodulatory properties that has been used in veterinary medicine for two decades. It is a calcineurin inhibitor whose principal mode of action is to inhibit T cell activation. The drug is principally absorbed from the small intestine and is metabolised in the intestine and liver by the cytochrome P450 enzyme system. Ciclosporin is known to interact with a wide range of pharmacological agents. Numerous studies have demonstrated good efficacy for the management of canine atopic dermatitis and this has been a licensed indication since 2003. In addition to the treatment of atopic dermatitis, it has been used as an aid in the management of numerous other dermatological conditions in animals including perianal fistulation, sebaceous adenitis, pododermatitis, chronic otitis externa and pemphigus foliaceus. This article reviews the mode of action, pharmacokinetics, indications for use and efficacy of ciclosporin in veterinary dermatology.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/24682697/