Peer-reviewed veterinary case report
Ciclosporin treatment for brain inflammation in three dogs
By Gnirs, K·Published in The Journal of small animal practice·2006·View original on PubMed →
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Original publication title: Ciclosporin treatment of suspected granulomatous meningoencephalomyelitis in three dogs.
- Species:
- dog
Plain-English summary
Three dogs with suspected granulomatous meningoencephalomyelitis, a serious brain and spinal cord condition, were treated with ciclosporin after initial glucocorticoid therapy. The dogs showed improvement in their symptoms, which included neurological issues, after starting ciclosporin at a dose of 10 mg/kg daily, then reducing to 5 mg/kg. While it took longer for the dogs to show improvement compared to glucocorticoids, they eventually had similar results. The treatment was well-tolerated, with only mild vomiting reported as a side effect.
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Abstract
Granulomatous meningoencephalomyelitis is an idiopathic disease of the central nervous system of presumed dysimmune origin. This disorder is characterised histologically by an angiocentric inflammatory reaction involving the brain, the spinal cord, and/or the leptomeninges. To date, the standard treatment for granulomatous meningoencephalomyelitis consists of immunosuppressive dosages of glucocorticoids. Ciclosporin A, a potent immunosuppressive agent that blocks the transcription of cytokine genes in activated T cells, has been proposed as a therapeutic alternative. In the present study of three dogs with suspected granulomatous meningoencephalomyelitis, microemulsified ciclosporin, at a dose of 10 mg/kg once daily for at least six weeks, then reducing to 5 mg/kg daily, was administered after a variable period of glucocorticoid treatment, and resulted in a complete resolution of clinical signs. Satisfactory improvement of clinical signs after ciclosporin administration took more time than after glucocorticoid administration. Six weeks after the beginning of ciclosporin treatment, clinical results were similar to those obtained with prednisolone. Adverse effects were minimal with ciclosporin, with only intermittent vomiting.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/16573763/