Peer-reviewed veterinary case report
Ciprofloxacin and ofloxacin levels in dog eyes before cataract surgery
By Yu-Speight, Audrey W et al.·Published in Veterinary ophthalmology·2005·Central Texas Veterinary Ophthalmology, United States·View original on PubMed →
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Original publication title: Ciprofloxacin and ofloxacin aqueous humor concentrations after topical administration in dogs undergoing cataract surgery.
- Species:
- dog
Plain-English summary
A group of dogs undergoing cataract surgery received either ciprofloxacin or ofloxacin eye drops before their procedure to see which medication worked better at preventing infections. The results showed that ofloxacin was more effective, as it reached higher levels in the eye fluid and was better at fighting off common bacteria that could cause infections. In contrast, ciprofloxacin did not reach the necessary levels to effectively combat these bacteria. Based on this study, ofloxacin is recommended as the better choice for preventing infections in dogs having cataract surgery.
People also search for: dog cataract surgery eye drops · ofloxacin for dogs · ciprofloxacin effectiveness in dogs
Abstract
OBJECTIVE: To determine if preoperative topical administration of ciprofloxacin or ofloxacin results in aqueous humor drug concentrations that exceed the MIC(90) of common ocular contaminants in dogs undergoing cataract surgery. PROCEDURES: Twelve dogs were treated with topical 0.3% ciprofloxacin and 13 dogs with topical 0.3% ofloxacin once the night before surgery, and then with 1 drop of ciprofloxacin or ofloxacin every 15 min for 2 h immediately before surgery. Aqueous humor samples were taken from each eye immediately before the incision was made and frozen at -70 degrees C. First eye samples (S1) were taken closer to the time of topical treatments than second eye samples (S2). Samples were analyzed by high performance liquid chromatography (HPLC) at the North Carolina State University (NCSU) Clinical Pharmacology laboratory. RESULTS: In ciprofloxacin patients, S1 concentrations were 0.03-0.69 (0.17 median) microg/mL, and S2 concentrations were 0.09-0.95 (0.36 median) microg/mL. Aqueous humor concentrations did not exceed the MIC90 of Streptococcus sp. Few eyes (1/12 OU) exceeded the MIC90 for Staphylococcus sp. or Corynebacterium sp.; moderate numbers (5/12 S1; 8/12 S2) exceeded the MIC90 for E. coli. In ofloxacin patients, S1 concentrations were 0.48-2.81 (1.05 median) microg/mL, and S2 concentrations were 0.45-3.63 (1.30 median) microg/mL. Although few eyes (<or=2/13 OU) exceeded the MIC90 for Streptococcus sp. or Corynebacterium sp., moderate numbers (7/13 S1, 9/13 S2) exceeded the MIC90 for Staphylococcus sp. and most eyes (12/13 OU) exceeded the MIC90 for Bacillus sp. All eyes exceeded the MIC90 for E. coli. CONCLUSIONS: Ofloxacin has higher corneal penetration and ability to exceed MIC90 of common ocular contaminants than ciprofloxacin, and would be a more appropriate prophylactic choice for canine cataract patients.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/15910371/