Peer-reviewed veterinary case report
T regulatory cell levels in dogs with experimental atopic dermatitis
By Rostaher, Ana et al.·Published in Veterinary Dermatology·2018·Clinic for Small Animal Internal Medicine Vetsuisse Faculty University of Zurich Winterthurerstrasse 260 8057 Zurich Switzerland·View original on Crossref →
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Original publication title: Circulating CD4(+)CD25(+)Foxp3(+) T regulatory cell levels in an experimental model of canine atopic dermatitis
- Species:
- dog
Plain-English summary
Eight beagle dogs with no previous allergies were tested for atopic dermatitis (a skin condition caused by allergies) after being exposed to house dust mites. After the exposure, researchers found that the dogs had more T regulatory cells, which help control immune responses, but lower levels of a specific protein (TGF-β) that usually helps regulate inflammation. Most dogs had very low levels of another protein (IL-10) that also helps reduce inflammation. This study suggests that T regulatory cells play a role in the development of skin allergies in dogs, but more research is needed to understand how they work with other immune cells.
People also search for: dog skin allergies treatment · beagle atopic dermatitis symptoms · house dust mite allergy in dogs
Abstract
BackgroundThe pathogenesis of canine atopic dermatitis (cAD) is characterized immunologically by an imbalanced T‐cell response. Mechanisms of immune regulation in cAD have not yet been completely elucidated.ObjectivesTo investigate peripheral blood T regulatory (Treg) cells and their associated cytokines (TGF‐β and IL‐10) in an experimental model of cAD.AnimalsEight beagle dogs that were initially naïve and subsequently sensitized to house dust mites (HDM).Methods and materialsT regulatory cell phenotyping was performed by flow‐cytometric analysis on peripheral blood; serum cytokine levels were measured by ELISA, before sensitization and after challenge with HDM allergens. Additionally, clinical scores and allergen‐specific IgE were determined.ResultsAfter challenge of sensitized dogs to HDM allergen, a significant increase of Treg cells and simultaneous decrease in the serum TGF‐β were observed. However, in most dogs, serum IL‐10 values were below the detection limit. Treg cell proportions before sensitization were significantly negatively correlated with the HDM‐specific IgE levels and clinical scores after induction of AD signs.Conclusion and clinical importanceThe results confirm that Treg responses are involved in the pathogenesis of an experimental model cAD. Further investigations are required to clarify the precise immune modulating function of canine Treg cells and their interplay with other immune cell types.
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Search related cases →Original publication on Crossref: https://doi.org/10.1111/vde.12693