Peer-reviewed veterinary case report
T regulatory cell levels in dogs with experimental atopic dermatitis
By Rostaher, Ana et al.·Published in Veterinary dermatology·2018·Clinic for Small Animal Internal Medicine·View original on PubMed →
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Original publication title: Circulating CD4(+)CD25(+)Foxp3(+) T regulatory cell levels in an experimental model of canine atopic dermatitis.
- Species:
- dog
Plain-English summary
A group of eight Beagle dogs developed skin problems after being exposed to house dust mites, which caused symptoms of canine atopic dermatitis (cAD). Researchers found that after the dogs were sensitized to the allergens, there was an increase in certain immune cells (T regulatory cells) but a decrease in a specific protein (TGF-β) that helps regulate the immune response. Most dogs had very low levels of another protein (IL-10) that also helps control inflammation. These findings suggest that the immune system's response plays a significant role in the development of cAD, but more research is needed to understand how these immune cells interact.
People also search for: dog skin problems house dust mites · Beagle atopic dermatitis treatment · canine allergy immune response
Abstract
BACKGROUND: The pathogenesis of canine atopic dermatitis (cAD) is characterized immunologically by an imbalanced T-cell response. Mechanisms of immune regulation in cAD have not yet been completely elucidated. OBJECTIVES: To investigate peripheral blood T regulatory (Treg) cells and their associated cytokines (TGF-β and IL-10) in an experimental model of cAD. ANIMALS: Eight beagle dogs that were initially naïve and subsequently sensitized to house dust mites (HDM). METHODS AND MATERIALS: T regulatory cell phenotyping was performed by flow-cytometric analysis on peripheral blood; serum cytokine levels were measured by ELISA, before sensitization and after challenge with HDM allergens. Additionally, clinical scores and allergen-specific IgE were determined. RESULTS: After challenge of sensitized dogs to HDM allergen, a significant increase of Treg cells and simultaneous decrease in the serum TGF-β were observed. However, in most dogs, serum IL-10 values were below the detection limit. Treg cell proportions before sensitization were significantly negatively correlated with the HDM-specific IgE levels and clinical scores after induction of AD signs. CONCLUSION AND CLINICAL IMPORTANCE: The results confirm that Treg responses are involved in the pathogenesis of an experimental model cAD. Further investigations are required to clarify the precise immune modulating function of canine Treg cells and their interplay with other immune cell types.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/30318823/