Peer-reviewed veterinary case report
Cytokine levels in dogs with mitral valve disease at different stages
By Zois, Nora E et al.·Published in Veterinary journal (London, England : 1997)·2012·Department of Basic Animal and Veterinary Sciences·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Circulating cytokine concentrations in dogs with different degrees of myxomatous mitral valve disease.
- Species:
- dog
Plain-English summary
A group of dogs with myxomatous mitral valve disease (MMVD), including Cavalier King Charles Spaniels and Cairn terriers, were studied to see how certain proteins in their blood (cytokines) related to their heart condition. The dogs with congestive heart failure (CHF) had higher levels of a specific cytokine called MCP-1 compared to those with mild heart issues. As the severity of their heart disease increased, levels of other cytokines like IL-2 and IL-7 decreased. This research suggests that monitoring these cytokines could help understand and manage heart disease in dogs better.
People also search for: dog heart disease symptoms · Cavalier King Charles Spaniel CHF treatment · myxomatous mitral valve disease in dogs
Abstract
Cytokines have been associated with the progression of congestive heart failure (CHF) in humans and may be implicated in the pathophysiology of myxomatous mitral valve disease (MMVD) in dogs. The aim of this study was to determine the serum concentrations of cytokines in dogs with MMVD. The study included 16 Cairn terriers with no or minimal mitral regurgitation (MR), 41 Cavalier King Charles Spaniels (CKCS) with different degrees of MR and 11 dogs of different breeds with CHF due to MMVD. Granulocyte-macrophage colony-stimulating factor, interferon-γ, interleukin (IL)-2, IL-6, IL-7, IL-8, IL-10, IL-15, IL-18, keratinocyte-derived chemokine, interferon-γ-induced protein and monocyte chemoattractant protein-1 (MCP-1) were measured using a canine-specific multiplex immunoassay. CHF dogs had significantly higher MCP-1 concentrations than dogs with no or minimal MR. Among the CKCS, IL-2 and IL-7 decreased with increasing left atrial size and IL-7 also decreased with increasing MR. IL-8 decreased with increasing left ventricular end-systolic internal dimensions. MCP-1 was increased in CHF dogs compared to healthy control dogs and IL-2, IL-7 and IL-8 decreased with increasing indices of disease severity. The results suggest a role for these cytokines in canine MMVD and CHF.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/21696985/