Peer-reviewed veterinary case report
Low blood let-7g levels in Bernese Mountain dogs with cancer
By Børresen, B et al.·Published in Veterinary and comparative oncology·2017·Department of Veterinary Clinical and Animal Sciences·View original on PubMed →
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Original publication title: Circulating let-7g is down-regulated in Bernese Mountain dogs with disseminated histiocytic sarcoma and carcinomas - a prospective study.
- Species:
- dog
Plain-English summary
A group of Bernese Mountain dogs with cancer, including some with a serious type called disseminated histiocytic sarcoma, showed lower levels of a specific microRNA (let-7g) in their blood compared to healthy dogs. This microRNA is important because it helps suppress tumors. The study suggests that measuring let-7g could be a useful way to detect cancer early in these dogs. More research is needed to confirm its effectiveness as a non-invasive test for cancer in Bernese Mountain dogs.
People also search for: Bernese Mountain dog cancer symptoms · let-7g microRNA cancer test · early cancer detection in dogs
Abstract
Cancer is a prevalent cause of mortality in Bernese mountain dogs (BMDs). Circulating microRNAs (miRNAs) are found in blood and have been identified as promising biomarkers in various neoplastic diseases in humans. In the current study, the expression profile of different types of miRNAs was investigated in healthy BMDs and BMDs with cancer. Seven healthy and six non-treated BMDs with cancer [four with disseminated histiocytic sarcomas (DHS)] were enrolled in this study. Clinical evaluations including physical examination, blood analysis, urinalysis and diagnostic imaging were performed on all dogs. Twenty-four different miRNAs were profiled from RNA isolated from whole blood preserved in PAXgenetubes using quantitative real-time PCR (qPCR). The miRNA let-7g was significantly down-regulated in dogs with cancer (P = 0.002) and dogs with DHS (P = 0.011) compared with healthy controls. This miRNA is a known tumour suppressor and further analyses are warranted to assess its value as a non-invasive biomarker for early detection of different types of cancer in BMDs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/26792388/