Peer-reviewed veterinary case report
Blood pressure and kidney disease effects on cat hormone levels
By Lourenço, Bianca N et al.·Published in Journal of veterinary internal medicine·2026·Department of Small Animal Medicine & Surgery, United States·View original on PubMed →
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Original publication title: Circulating renin-angiotensin-aldosterone system markers in cats with non-hypertensive chronic kidney disease or systemic arterial hypertension.
- Species:
- cat
Plain-English summary
A group of cats with chronic kidney disease (CKD) and high blood pressure (hypertension) were studied to see how their bodies produced certain hormones related to blood pressure and kidney function. The researchers found that cats with untreated hypertension had lower levels of specific hormones compared to healthy cats. When these hypertensive cats were treated with amlodipine, a common blood pressure medication, their hormone levels increased, indicating a response to the treatment. However, no significant differences in another hormone, aldosterone, were observed between the groups or before and after treatment.
People also search for: cat chronic kidney disease symptoms · cat high blood pressure treatment · amlodipine for cats hypertension
Abstract
BACKGROUND: Information on the classical and alternative circulating renin-angiotensin-aldosterone systems (RAAS) in cats with non-hypertensive chronic kidney disease (NHT-CKD) or systemic arterial hypertension (SAH) is limited. Age and diet affect the RAAS. HYPOTHESIS/OBJECTIVES: To compare serum equilibrium concentrations of angiotensin peptides and aldosterone in healthy cats and cats with NHT-CKD or untreated SAH, and to evaluate changes in these concentrations in hypertensive cats administered amlodipine. ANIMALS: Client-owned cats with NHT-CKD (serum creatinine ≥ 1.6 mg/dL, systolic blood pressure [SBP] < 160 mmHg; n = 17), SAH (SBP ≥ 160 mmHg or ≥ 150 mmHg with hypertensive ocular lesions; n = 6), or normal SBP (<140 mmHg) and kidney function (n = 17). METHODS: Prospective, single-center, observational study. Cats underwent indirect SBP measurement and clinicopathologic analyses. Serum was obtained contemporaneously in all cats, and after 2-4 weeks of amlodipine therapy in hypertensive cats, for evaluation of angiotensin I, II, III, IV, 1-5, and 1-7, and aldosterone. RESULTS: Adjusting for diet, age, or both modified the conclusions of statistical comparisons for several variables. Mean serum angiotensin I, II, and III concentrations were lower in cats with untreated SAH vs healthy controls across unadjusted and diet-, age-, or both diet- and age-adjusted linear mixed models (geometric mean [95% CI] angiotensin I, 9.02 [3.05-26.62] vs 29.78 [21.15-41.94] pmol/L; angiotensin II, 33.63 [12.25-92.26] vs 124.24 [90.52-170.51] pmol/L; angiotensin III, 1.56 [0.88-2.79] vs 7.96 [5.35-11.86] pmol/L; all P ≤ .038). Controlling for diet but not age, angiotensin II (P = .043) and III (P = .019) were also lower in cats with NHT-CKD vs controls. All angiotensin peptides, except for angiotensin IV, significantly increased in hypertensive cats during amlodipine therapy. Serum aldosterone did not differ between groups, or before and after amlodipine in hypertensive cats. CONCLUSIONS AND CLINICAL IMPORTANCE: Evidence of circulating RAAS activation in cats with NHT-CKD or untreated SAH was not found.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/42117720/