Peer-reviewed veterinary case report
Cisplatin causes vomiting and stomach rhythm problems in dogs and may
By Yu, Xiaoyun et al.·Published in Digestive diseases and sciences·2009·Union Hospital, China·View original on PubMed →
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Original publication title: Cisplatin-induced gastric dysrhythmia and emesis in dogs and possible role of gastric electrical stimulation.
- Species:
- dog
Plain-English summary
Seven dogs were studied to see how a chemotherapy drug called cisplatin affected their stomach activity and caused vomiting. The dogs experienced vomiting and signs of nausea after receiving cisplatin, which disrupted their normal stomach rhythms. However, when gastric electrical stimulation was applied, it helped reduce the vomiting and nausea symptoms, even though it didn't fix the stomach rhythm issues. This suggests that while cisplatin can cause significant stomach problems, gastric electrical stimulation might be a helpful treatment for managing vomiting caused by chemotherapy.
People also search for: dog vomiting after chemotherapy · cisplatin side effects in dogs · gastric stimulation for dog nausea
Abstract
The aim of this study was to investigate the effect of cisplatin on gastric myoelectrical activity and the role of gastric electrical stimulation in the treatment of cisplatin-induced emesis in dogs. Seven dogs implanted with electrodes on the gastric serosa were used in a two-session study. Cisplatin was infused in both the control session and the gastric electrical stimulation session, and gastric electrical stimulation was applied in the gastric electrical stimulation session. Gastric slow waves and emesis, as well as behaviors suggestive of nausea, were recorded during each session. The results were as follows: (1) cisplatin induced vomiting and other symptoms and induced gastric dysrhythmia. The percentage of normal slow waves decreased significantly during the 2.5 h before vomiting (P=0.01) and the period of vomiting (P<0.001). (2) Gastric electrical stimulation reduced emesis and the symptoms score. The total score in the control session was higher than that in the gastric electrical stimulation session (P=0.02). However, gastric electrical stimulation had no effects on gastric dysrhythmia. It is concluded that cisplatin induces emesis and gastric dysrhythmia. Gastric electrical stimulation may play a role in relieving chemotherapy-induced emetic responses and deserves further investigation.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/18754094/