Peer-reviewed veterinary case report
Nerve tumor with glucose transporter 1 tested in a 4-year-old
By Cornelis, I et al.·Published in Journal of comparative pathology·2012·Ghent University·View original on PubMed →
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Original publication title: Claudin-1 and glucose transporter 1 immunolabelling in a canine intraneural perineurioma.
- Species:
- dog
Plain-English summary
A 4-year-old male Leonberger was experiencing nerve issues and was diagnosed with a tumor affecting the median nerve after a neurological exam, nerve testing, and ultrasound. The tumor was surgically removed and examined, revealing abnormal nerve tissue with specific cell patterns. Further tests confirmed the diagnosis of an intraneural perineurioma, a type of tumor that affects nerve sheaths. The surgery was successful, and the dog was treated based on the findings.
People also search for: Leonberger nerve tumor treatment · dog peripheral nerve sheath tumor · canine intraneural perineurioma symptoms
Abstract
A 4-year-old male leonberger was diagnosed tentatively with a peripheral nerve sheath tumour of the median nerve based on neurological examination, electrodiagnostic testing and ultrasound evaluation. The lesion was excised and submitted for pathological examination. Histopathology revealed an irregularly enlarged, hypercellular nerve fascicle with neoplastic tissue consisting of a uniform population of spindle-shaped cells arranged in 'pseudo-onion bulb-like' whorls around axons. Minimal anisocytosis and anisokaryosis were present, together with a low mitotic index. Electron microscopy showed spindle cells with a discontinuous basal membrane and intercellular junctions, as well as pinocytotic vesicles. Immunohistochemistry for neurofilament, S100 and glucose transporter 1 was negative, whereas labelling for claudin-1 and laminin was positive. Based on these observations, a definitive diagnosis of intraneural perineurioma was made.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/22297071/