Peer-reviewed veterinary case report
Ivermectin poisoning cleared by lipid dialysis in 2 Australian
By Londoño, Leonel A et al.·Published in Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)·2017·Department of Small Animal Clinical Sciences, United States·View original on PubMed →
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Original publication title: Clearance of plasma ivermectin with single pass lipid dialysis in 2 dogs.
- Species:
- dog
Plain-English summary
Two Australian Shepherd dogs were brought in after showing signs of ivermectin poisoning, which can happen if they have a genetic mutation that affects how they process the drug. Initially, they received intravenous lipid treatment and supportive care, but their condition worsened, leading to breathing problems that required mechanical ventilation. To help clear the ivermectin from their systems, a treatment called single pass lipid dialysis was used, which showed some effectiveness in one of the dogs. Fortunately, both dogs eventually recovered after several days on the ventilator.
People also search for: ivermectin poisoning in dogs · Australian Shepherd breathing problems · dog ivermectin treatment options
Abstract
OBJECTIVE: To describe the use of single pass lipid dialysis (SPLD) for treatment of ivermectin toxicosis in 2 Australian Shepherd dogs with the ABCB1-1Δ gene mutation. CASE SERIES SUMMARY: Two Australian Shepherd dogs were presented for treatment of ivermectin toxicosis. Dogs were initially treated with intravenous lipid emulsion and supportive care, without improvement of clinical signs. They both developed respiratory paralysis and required mechanical ventilation. In order to increase the clearance of circulating ivermectin, SPLD was performed using dialysate containing 5% lipid. Blood samples were obtained immediately before and after dialysis and analyzed for serum ivermectin concentration. Ivermectin reduction ratio was calculated at 29% and 39% for each dog, respectively. When compared to intrinsic total body ivermectin clearance, only the second dog had a relative improvement of plasma clearance following SPLD. Both dogs were confirmed to be homozygous for ABCB1-1Δ gene mutations. Both dogs remained ventilator dependent for several days and ultimately made a full recovery. NEW OR UNIQUE INFORMATION PROVIDED: SPLD may be an adjunctive detoxification strategy for highly lipophilic toxins such as ivermectin.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/28117946/