Peer-reviewed veterinary case report
Gum growths called peripheral giant cell granulomas in dogs and their
By Desoutter, A V et al.·Published in Veterinary pathology·2012·Department of Pathobiology, United States·View original on PubMed →
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Original publication title: Clinical and histologic features of 26 canine peripheral giant cell granulomas (formerly giant cell epulis).
- Species:
- dog
Plain-English summary
A group of dogs with a type of gum growth called peripheral giant cell granuloma (formerly known as giant cell epulis) was studied to understand its features and behavior. These growths were found mostly in the upper jaw and were made up of giant cells and other cells in a collagen-like structure. In the cases where the dogs had surgery to remove the growths, only two out of sixteen had them come back afterward. Overall, these growths are not very likely to return after being surgically removed, which is good news for pet owners facing this issue.
People also search for: dog gum growth treatment · giant cell granuloma in dogs · dog oral tumor recurrence
Abstract
Clinical and histologic features of 26 cases of canine peripheral giant cell granuloma (formerly giant cell epulis) are reported. Two main histologic categories were evident: (1) "classic" peripheral giant cell granuloma, characterized by variable numbers of multinucleated giant cells (MNGCs) admixed with densely cellular mononuclear spindle-shaped cells in variable amounts of collagenous matrix, and (2) the "collision" peripheral giant cell granuloma, with features of both a peripheral giant cell granuloma and a fibromatous epulis of periodontal ligament origin. In the 16 dogs for which the outcome was known, 2 peripheral giant cell granulomas recurred after excision. No age or sex predilection was evident; however, lesions were more common in maxillary than in mandibular gingiva. In contrast to cats, peripheral giant cell granulomas in dogs behave like fibromatous epulides of periodontal ligament origin and seldom recur after excision. Positive staining with TRAP (tartrate-resistant acid phosphatase) of the MNGCs and a fraction of the mononuclear cell population is consistent with osteoclastic origin.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/22411551/