Peer-reviewed veterinary case report
Treatment with PLR 120 improved skin lesions in cats
By Scarampella, F et al.·Published in Veterinary dermatology·2001·Studio Dermatologico Veterinario, Italy·View original on PubMed →
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Original publication title: Clinical and histological evaluation of an analogue of palmitoylethanolamide, PLR 120 (comicronized Palmidrol INN) in cats with eosinophilic granuloma and eosinophilic plaque: a pilot study.
- Species:
- cat
Plain-English summary
Fifteen cats with skin issues called eosinophilic granuloma and eosinophilic plaque were treated with a medication called PLR 120 for a month. This treatment helped reduce their symptoms, with about 67% of the cats showing improvement in their skin lesions after 15 and 30 days. While the number of certain immune cells (mast cells) didn't change significantly, the granules they contained increased, suggesting the treatment was effective. Overall, PLR 120 appears promising for helping cats with these specific skin problems.
People also search for: cat eosinophilic granuloma treatment · cat skin plaque medication · eosinophilic plaque in cats symptoms
Abstract
Fifteen cats with eosinophilic granuloma or eosinophilic plaque were given PLR 120 at the dosage of 10 mg kg-1 twice daily for one month. PLR-120 down-modulates mast cell degranulation via a receptor-mediated mechanism. No other drugs were permitted and cats were kept free of parasites throughout the study. A clinical evaluation and skin biopsies were performed before and after the treatment. Clinical improvement was assessed at 15 and 30 days. Mast cell numbers were counted and their granular content was assessed by densitometric analysis on toluidine blue-stained sections before and after the treatment. Ten of 15 (67%) cats showed clinical improvement of signs and lesions. There was no significant difference between mast cell numbers in skin biopsies taken before and after the trial, whereas the number of granules was significantly increased (P < 0.009). This pilot study suggests that PLR-120 might be a useful drug for the treatment of eosinophilic granuloma and eosinophilic plaque.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/11301536/