Peer-reviewed veterinary case report
Dog eye dryness and inflammation improved with 2% cyclosporine
By Izci, C et al.·Published in Biotechnic & histochemistry : official publication of the Biological Stain Commission·2015·Selcuk University·View original on PubMed →
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Original publication title: Clinical and light microscopic studies of the conjunctival tissues of dogs with bilateral keratoconjunctivitis sicca before and after treatment with topical 2% cyclosporine.
- Species:
- dog
Plain-English summary
Twelve dogs with dry eye (keratoconjunctivitis sicca) were treated with a 2% eye drop solution of cyclosporine for 45 days to see if it would help their symptoms. The dogs showed significant improvement in tear production and the health of their eye tissues, with more healthy cells and fewer inflammatory cells after treatment. Even after stopping the drops, their tear production remained better than before treatment, although it did decrease slightly over time. Overall, the cyclosporine eye drops effectively relieved the dogs' dry eye symptoms and improved their eye health.
People also search for: dog dry eye treatment · cyclosporine for dogs eyes · dog eye drops for keratoconjunctivitis sicca
Abstract
We determined the concentrations of goblet and immune cells in conjunctival imprints and tissues of canines with keratoconjunctivitis sicca (KCS) before and after cyclosporine A (CsA) treatment. Twelve dogs with bilateral KCS were assigned to three groups: untreated, treatment group 1, and treatment group 2. The treatment groups were treated topically with 2% ophthalmic CsA solution for 45 days; CsA treatment group 2 was followed for an additional 30 days after discontinuation of the drug. Schirmer tear test (STT) scores were recorded prior to CsA treatment and on alternate days throughout the experiment. CsA treatment improved the STT scores, restored conjunctival histology, increased goblet and epithelial cell numbers, and decreased numbers of inflammatory cells. Although the STT scores regressed slightly at day 30 after discontinuing the treatment, the scores were higher than the baseline values. Topical CsA treatment resolved clinical signs of KCS, improved STT scores and restored normal conjunctival histology.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/25747049/