Peer-reviewed veterinary case report
Bacterial urine infections in dogs with high cortisol levels
By Machado, Letícia et al.·Published in Comparative immunology, microbiology and infectious diseases·2021·Federal University of Rio Grande do Sul, Brazil·View original on PubMed →
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Original publication title: Clinical and microbiological characterization of subclinical bacteriuria and sporadic bacterial cystitis in dogs with spontaneous hypercortisolism.
- Species:
- dog
Plain-English summary
A group of dogs with high cortisol levels (spontaneous hypercortisolism) showed signs of urinary tract infections, including subclinical bacteriuria (bacteria in urine without symptoms) and sporadic bacterial cystitis (painful bladder infection). The most common bacteria found was E. coli. When treated with antibiotics based on the bacteria's sensitivity, about 75% of the dogs showed improvement. However, some dogs with subclinical bacteriuria had persistent infections, indicating that treatment guidelines may need to be reconsidered for these cases.
People also search for: dog urinary tract infection treatment · E. coli in dog urine · high cortisol dog symptoms
Abstract
Study's aims were to characterize subclinical bacteriuria (SB) and sporadic bacterial cystitis (SBC) in dogs with spontaneous hypercortisolism (HC). Prospective cross-sectional design divided patients as newly diagnosed (n = 27), poorly controlled (n  = 21), well controlled (n  = 34), and controls (n  = 19). Urine culture positive results were identified by MALDI-TOF and submitted to antibiogram. Escherichia coli was the most common microorganism (36%). The majority of positive cultures in HC were SB (12.2%). All 4.1% SBC cases were in well controlled HC cases. Bacteriuria correlated with low urine specific gravity and low lymphocyte count. HC degree of control correlated with leukocyturia. SB/SBC cases were treated based in antimicrobial susceptibility leading to microbiological cure in 75% of HC cases. Persistent infections occurred only in SB cases, all by E. coli which became more resistant. SB/SBC prevalence in canine HC is actually lower. Further evidence for current ISCAID guideline contraindication for SB treatment due to HC were provided.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/33609989/