Peer-reviewed veterinary case report
PCR test for Mycoplasma felis in cats with lower breathing problems
By Thibaud Robin et al.·Published in Journal of Feline Medicine and Surgery·2024·Centre Hospitalier Vétérinaire Fregis – IVC Evidensia France, Paris, France, GB·View original on DOAJ →
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Original publication title: Clinical and prognostic relevance of PCR detection in feline lower respiratory tract disease
- Species:
- cat
Plain-English summary
A group of cats with breathing problems was studied to see if the presence of a bacteria called Mycoplasma felis affected their health. Out of 55 cats, those with Mycoplasma felis showed more severe lung issues on X-rays and had higher levels of certain white blood cells in their lung fluid. However, both groups of cats responded similarly to treatment, and having Mycoplasma felis did not seem to worsen their chances of recovery. Most cats with the bacteria were treated with antibiotics, but the overall outcome was similar for both groups.
People also search for: cat breathing problems treatment · Mycoplasma felis in cats · cat pneumonia antibiotics
Abstract
Objectives The aim of this retrospective cohort study was to compare two groups of cats with lower respiratory tract disease, one with Mycoplasma felis detected by PCR in the bronchoalveolar lavage fluid (BALF) (M+) and the other without (M–), with regard to signalment, clinical signs, diagnostic results, treatment response and survival. Methods All cats for which M felis was investigated by PCR in BALF between 2016 and 2023 were included. Cats with evidence of oropharyngeal contamination, or for which PCR results were under the quantification level, or without follow-up information were excluded. Cats that had received antibiotics effective against M felis before BALF collection were excluded if PCR results were negative. Follow-up information was retrieved from the medical records and by contacting referring veterinarians and owners. Results A total of 55 cats were included (19 in the M+ group and 36 in the M– group). Significant differences were detected between the two groups in the prevalence of systemic signs (M+: 0%, M–: 28%; P = 0.01), bronchial collapse on bronchoscopy (M+: 28%, M–: 6%; P = 0.03), radiographic alveolar lesions (M+: 57%, M–: 24%; P = 0.04), and percentage of neutrophils (M+: 65%, M–: 35%; P = 0.002) and eosinophils (M+: 9%, M–: 25%; P = 0.03) in the BALF. Antibiotics were used more frequently in M+ cats (M+: 90%, M–: 42%; P = 0.001) than in M– cats. No significant difference was found in treatment response (short term: P = 0.94, long term: P = 0.28) and risk of death ( P = 0.42) between the two groups. Conclusions and relevance The presence of radiographic alveolar lesions and neutrophilia in BALF was significantly associated with the detection of M felis in BALF. This association might be causal, consequential or contextual (ie, sharing the same cause). The detection of M felis in BALF did not negatively impact prognosis but the necessity to treat M felis using targeted antibiotics remains to be determined.
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Search related cases →Original publication on DOAJ: https://doi.org/10.1177/1098612X241297870