Peer-reviewed veterinary case report
Bone healing in two dogs after radial fracture treated with BMP-2
By Park, Jueun et al.·Published in In vivo (Athens, Greece)·2018·Department of Veterinary Surgery, South Korea·View original on PubMed →
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Original publication title: Clinical Application of Bone Morphogenetic Protein-2 Microcarriers Fabricated by the Cryopolymerization of Gelatin Methacrylate for the Treatment of Radial Fracture in Two Dogs.
- Species:
- dog
Plain-English summary
Two dogs with broken bones in their front legs were treated with a special implant that helps bones heal faster. This implant contained a growth factor called bone morphogenetic protein-2, which was delivered in a way that allowed it to work effectively over time. After surgery, both dogs showed significant improvement: their fractures healed well, the bone lines disappeared, and they were able to walk normally again. This treatment helped them regain full use of their legs.
People also search for: dog broken leg treatment · bone healing in dogs · BMP-2 for dog fractures
Abstract
Bone morphogenetic protein-2 (BMP-2) effectively induces bone healing. However, the efficacy of BMP-2 relies heavily on its delivery vehicle because of its short half-life. We utilized a microcarrier fabricated by the cryopolymerization of gelatin methacrylate (cryoGelMA) infused with bone morphogenetic protein-2 (cryoGelMA-BMP-2) for the sustained and localized release of growth factors. Two dogs with radius and ulnar fractures were treated with implanted cryoGelMA-BMP-2 to accelerate bone healing. The cases were followed up for 6 months and 2 months after surgery, respectively. Distinctive healing processes were observed. The operated limb regained its premorbid function, the fracture line disappeared, and the gait was functionally stable. Implantation of cryoGelMA-BMP-2 resulted in the successful healing of bone fractures.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/29695563/