Peer-reviewed veterinary case report
Using iohexol blood test to check kidney function in cats
By Miyamoto, K·Published in Journal of feline medicine and surgery·2001·Angel Animal Hospital, Japan·View original on PubMed →
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Original publication title: Clinical application of plasma clearance of iohexol on feline patients.
- Species:
- cat
Plain-English summary
A group of 52 cats were evaluated for kidney function using a test called plasma clearance of iohexol (PCio), which helps measure how well the kidneys filter waste. The results showed that healthy cats had a higher kidney function rate compared to those with suspected or confirmed kidney disease, and especially those showing clear signs of kidney failure. This test can detect kidney issues earlier than traditional blood tests, which often miss early signs of kidney problems. By using PCio, veterinarians can better identify and manage chronic kidney disease in cats.
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Abstract
Glomerular filtration rate (GFR) was estimated by plasma clearance of iohexol (PCio) in 52 conscious cats presented for a variety of reasons to Angel Animal Hospital over a 2-year period. Cats were divided into four groups according to their clinical conditions and reasons for measuring PCio. The median PCio (ml/min/kg) was 3.68 in normal cats (NM), 2.39 in cats with suspected renal disease (SP), 1.35 in cats referred to confirm renal dysfunction (RD), and 0.84 in cats with apparent clinical signs of renal failure (RF). There was a significant difference between the results for each group. The respective medians of blood urea nitrogen (BUN) and plasma creatinine concentration (Pcr) (mg/dl) were 15 and 1.40 in NM cats, 21 and 1.71 in SP cats, 30 and 2.20 in RD cats, and 48 and 3.30 in RF cats. The reference values of BUN and Pcr were 21 +/- 7 mg/dl and 1.5 +/- 0.4 mg/dl (mean +/- SD). Diminished renal function could not be detected in SP cats by either BUN or Pcr, while a marked decrease of GFR was demonstrated before BUN and Pcr increased, indicating the insensitivity of BUN and Pcr in detecting renal dysfunction in cats. PCio can be performed non-invasively in conscious cats, which improves the veterinarian's ability to detect early stages of chronic renal disease.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/11876631/