Peer-reviewed veterinary case report
Measuring kidney function in cats using iohexol plasma clearance
By Miyamoto, K·Published in Journal of Feline Medicine and Surgery·2001·Angel Animal Hospital, 2827–1, Furushiro, Yatsushiro, Kumamoto 866–0043 Japan, Japan·View original on Crossref →
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Original publication title: Clinical Application of Plasma Clearance of Iohexol on Feline Patients
- Species:
- cat
Plain-English summary
A group of 52 cats was tested for kidney function using a non-invasive method called plasma clearance of iohexol (PCio). The results showed that healthy cats had a higher kidney filtration rate compared to those with suspected kidney disease or signs of kidney failure. This method was able to detect early kidney issues before traditional blood tests (like BUN and creatinine levels) showed any problems. Using PCio can help veterinarians identify chronic kidney disease in cats sooner, allowing for earlier treatment and better management of their health.
People also search for: cat kidney disease symptoms · how to test cat kidney function · early signs of kidney failure in cats
Abstract
Glomerular filtration rate (GFR) was estimated by plasma clearance of iohexol (PCio) in 52 conscious cats presented for a variety of reasons to Angel Animal Hospital over a 2-year period. Cats were divided into four groups according to their clinical conditions and reasons for measuring PCio. The median PCio (ml/min/kg) was 3.68 in normal cats (NM), 2.39 in cats with suspected renal disease (SP), 1.35 in cats referred to confirm renal dysfunction (RD), and 0.84 in cats with apparent clinical signs of renal failure (RF). There was a significant difference between the results for each group. The respective medians of blood urea nitrogen (BUN) and plasma creatinine concentration (Pcr) (mg/dl) were 15 and 1.40 in NM cats, 21 and 1.71 in SP cats, 30 and 2.20 in RD cats, and 48 and 3.30 in RF cats. The reference values of BUN and Pcr were 21 ± 7 mg/dl and 1.5 ± 0.4 mg/dl (mean ± SD). Diminished renal function could not be detected in SP cats by either BUN or Pcr, while a marked decrease of GFR was demonstrated before BUN and Pcr increased, indicating the insensitivity of BUN and Pcr in detecting renal dysfunction in cats. PCio can be performed non-invasively in conscious cats, which improves the veterinarian's ability to detect early stages of chronic renal disease.
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Search related cases →Original publication on Crossref: https://doi.org/10.1053/jfms.2001.0125