Peer-reviewed veterinary case report
How quick antibody tests check dog vaccine protection
By Ad, Y et al.·Published in Veterinary journal (London, England : 1997)·2023·William R. Pritchard Veterinary Medical Teaching Hospital, United States·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Clinical assessment of a point-of-care assay to determine protective vaccinal antibody titers to canine viral diseases.
- Species:
- dog
Plain-English summary
A group of 92 dogs were tested for protective antibody levels against canine distemper virus (CDV), canine parvovirus (CPV), and canine adenovirus (CAV) before their vaccinations. A new point-of-care test showed that most dogs had sufficient antibodies to be considered protected, but it also mistakenly identified some as protected when they weren't, particularly for CDV. While the test was very good at detecting protective levels, pet owners should be aware that it can sometimes give false results. This means that even if the test says your dog is protected, it’s still important to follow your vet's advice on vaccinations.
People also search for: dog vaccination antibody test · canine distemper virus protection · dog parvovirus vaccination schedule
Abstract
Guidelines recommend that dogs are vaccinated for canine distemper virus (CDV), canine parvovirus (CPV), and canine adenovirus (CAV) every 3 years. Alternatively, their antibody titers are measured and vaccines given when titers fall below a protective threshold. In this study, a point-of-care (POC) assay was compared to hemagglutination inhibition (for CPV) and virus neutralization (for CAV and CDV) assays to predict the need for revaccination Ninety-two dogs presented for vaccination were enrolled. The POC assay indicated protective titers against CDV in 79/80, CPV in 89/90, and CAV in 91/91 dogs with reference standard antibody measurements that were over a protective threshold. The sensitivity of the POC assay for to detect protective concentrations of CDV antibodies was 99% (95% confidence interval [CI 95%], 93.3-99.9%). Ten dogs were falsely considered protected against CDV by the POC assay with a specificity of 17% (CI 95%, 3.0-44.8%). The sensitivity of the POC assay for protective concentrations of CPV titers was 99% (CI 95%, 93.9-99.9%). The sensitivity of the POC assay to detect protective concentrations of CAV antibodies was 100% (CI 95%, 95.9-100%). Only classifying high-positive CDV and CPV titers on the POC assay as protective improved assay specificity to 100%, but sensitivity decreased to 51% and 76% respectively. This POC assay had a high sensitivity for the detection of protective antibody titers; however, some dogs were falsely categorized as protected, especially for CDV.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/37524148/