Peer-reviewed veterinary case report
Mid-pregnancy abortion in cats using aglepristone drug effects
By Fieni, Francis et al.·Published in Theriogenology·2006·National Veterinary School, France·View original on PubMed →
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Original publication title: Clinical, biological and hormonal study of mid-pregnancy termination in cats with aglepristone.
- Species:
- cat
Plain-English summary
A group of 61 pregnant cats received a medication called aglepristone to safely terminate their pregnancies. The treatment was effective in about 88.5% of the cases, with half of the cats experiencing pregnancy termination within three days. Some cats showed brief signs of depression and loss of appetite, but these were temporary and linked to the process of expelling the fetuses. Importantly, none of the cats developed any uterine infections after the procedure. Overall, aglepristone proved to be a safe option for mid-pregnancy termination in cats.
People also search for: cat pregnancy termination · aglepristone for cats · signs of cat pregnancy complications
Abstract
In order to evaluate the efficacy, the safety and the variation in plasma concentrations of estrogens, progesterone, PGFM, oxytocin, cortisol and prolactin after mid-pregnancy termination induced by aglepristone, 61 pregnant queens (33.3 + 4.2 days), were injected subcutaneously with 15 [corrected] mg/kg aglepristone, (Alizine) [corrected] repeated once 24 h later. Five queens served as control and received a placebo. The efficacy of aglepristone was 88.5% and termination of pregnancy was achieved in 50% of the queens within 3 days. Brief periods of depression and anorexia were noted in 9.3% of the queens before fetal expulsion (these symptoms were attributed to the phenomenon of fetal expulsions). Not one of the queens that aborted developed uterine disease. There were no changes in plasma concentrations of estrogen, prostaglandin, prolactin or oxytocin following aglepristone administration. However, there were significant increases in plasma concentrations of progesterone and cortisol 60 and 30 h, respectively, after aglepristone administration. Termination of pregnancy occurred with high plasma progesterone concentrations. Fetal expulsion was characterised by an increase in estrogen, PGFM and oxytocin concentrations, whereas prolactin and cortisol levels remained at a basal level.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/16563487/