Peer-reviewed veterinary case report
Dog with undescended testicles and hypospadias tested for genetic
By Cassata, R et al.·Published in Cytogenetic and genome research·2008·Faculty of Veterinary Medicine, Italy·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Clinical, cytogenetic and molecular evaluation in a dog with bilateral cryptorchidism and hypospadias.
- Species:
- dog
Plain-English summary
A Dalmatian dog was brought in with issues related to bilateral cryptorchidism (undescended testicles) and hypospadias (a condition where the urethra doesn't open at the tip of the penis). Tests showed that the dog's testosterone levels were extremely low, indicating hormonal issues. Despite various genetic tests, the exact cause of these conditions couldn't be clearly identified, as they can have many genetic factors involved. Unfortunately, the dog's reproductive health remained compromised due to these findings.
People also search for: Dalmatian cryptorchidism treatment · dog hypospadias symptoms · low testosterone in dogs
Abstract
The aim of this study was to estimate prognostic factors in a Dalmatian dog with bilateral cryptorchidism and hypospadias. Cytogenetic and molecular analyses revealed a normal karyotype (2n = 78,XY) and the presence of SRY, INSL3 and RXFP2 genes with a normal DNA sequence for SRY and RXFP2, while the INSL3 sequence differed slightly from the normal one due to a heterozygous nucleotide change involving amino acid 22 of the INSL3 dog precursor protein. Levels of plasmatic testosterone were only 0.01 ng/ml, while FSH and LH serum levels were not detectable. After the human chorionic gonadotropin (hCG) test, the serum testosterone level was 0.01 ng/ml. Therefore, the phenotypic aetiology of this subject can not be well-defined because cryptorchidism and hypospadias were frequent clinical features with high genetic heterogeneity.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/18467838/