Peer-reviewed veterinary case report
Diabetes linked to diestrus hormone changes in two female dogs
By Cui, Yi et al.·Published in Tierarztliche Praxis. Ausgabe K, Kleintiere/Heimtiere·2019·Department of Veterinary Clinical Sciences·View original on PubMed →
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Original publication title: Clinical diabetes mellitus in association with diestrus-induced acromegaly in 2 bitches.
- Species:
- dog
Plain-English summary
Two female dogs, aged 9 and 11 years, were brought to the vet because they were drinking and urinating a lot, vomiting, not eating, and seemed very tired. Upon examination, the vet noticed signs of tissue overgrowth, like large paws and breathing difficulties. One dog was diagnosed with diabetes, while the other had a more severe condition called diabetic ketoacidosis. Both dogs underwent surgery to remove their ovaries and uterus, which helped one dog go into remission from diabetes and improved the other dog's blood sugar control. This condition is rare but can happen in intact female dogs with diabetes and signs of acromegaly (abnormal growth).
People also search for: dog drinking a lot and urinating · dog vomiting and lethargy · diabetes treatment in dogs · acromegaly in dogs · ovariohysterectomy for diabetic dog
Abstract
Two intact bitches aged 9 and 11 years were referred due to chronic polyuria, polydipsia, vomiting, anorexia and progressive lethargy. On clinical examination, signs of tissue overgrowth (large paws, widened interdental space, pharyngeal stridor) were noticed. Diabetes mellitus (DM) was diagnosed in one dog (case 1) and diabetic ketoacidosis (DKA) in the other (case 2). There were increased IGF-1 values suggestive of hypersomatotropism. Progesterone values and pathological findings of the ovaries and uterus indicated diestrus. Diagnosis of diestrus-induced hypersomatotropism was made and ovariohysterectomy was performed in both dogs. Dog 1 also had multiple mammary neoplasms treated with bilateral mastectomy. Treatment resulted in diabetic remission in case 1 and improved glycaemic control in case 2. Overall, diestrus-induced hypersomatotropism is rare but should be considered in any intact diabetic bitch with acromegalic features. Ovariohysterectomy is recommended and associated with a fair to good prognosis.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/31212352/