Peer-reviewed veterinary case report
Short-term oral budesonide effects on stress hormones in dogs
By Tumulty, Joshua W et al.·Published in Journal of the American Animal Hospital Association·2004·E & M Bobst Hospital, United States·View original on PubMed →
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Original publication title: Clinical effects of short-term oral budesonide on the hypothalamic-pituitary-adrenal axis in dogs with inflammatory bowel disease.
- Species:
- dog
Plain-English summary
Six dogs with inflammatory bowel disease (IBD) were given a daily oral medication called budesonide for 30 days to see how it affected their hormone levels. The treatment led to a significant decrease in the activity of the hypothalamic-pituitary-adrenal (HPA) axis, which is important for stress response and hormone regulation. However, there were no noticeable changes in liver enzyme levels or urine concentration, and pet owners did not report any significant side effects related to the medication. Overall, while the budesonide affected hormone levels, it did not seem to cause major issues for the dogs during the trial.
People also search for: dog inflammatory bowel disease treatment · budesonide for dogs · side effects of budesonide in dogs
Abstract
Six dogs were entered into a 30-day, prospective, nonrandomized, uncontrolled clinical trial evaluating the effects of an oral preparation of budesonide on the hypothalamic-pituitary-adrenal (HPA) axis during therapeutic management of active inflammatory bowel disease. Oral budesonide, at a dose of 3 mg/m(2), was administered once daily. Upon entry and completion of the trial, serum basal cortisol, adrenocorticotropic (ACTH)-stimulated cortisol, endogenous ACTH concentration, serum alkaline phosphatase (SAP) activity, and urine specific gravity were evaluated, as well as owner assessment of glucocorticoid-associated side effects. Significant suppression of the HPA axis occurred. No significant differences in SAP activity, urine specific gravity, or owner-subjective assessments were detected.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/15007047/