Peer-reviewed veterinary case report
Reducing ciclosporin dose in cats with itchy skin safely
By Roberts, Elizabeth S et al.·Published in Journal of feline medicine and surgery·2016·1 Novartis Animal Health US, United States·View original on PubMed →
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Original publication title: Clinical efficacy and safety following dose tapering of ciclosporin in cats with hypersensitivity dermatitis.
- Species:
- cat
Plain-English summary
A group of 191 cats with skin allergies (hypersensitivity dermatitis) were treated with a medication called ciclosporin for four weeks. After that, the vet gradually reduced the dosage frequency from daily to every other day or twice a week, depending on how well the cats responded. Most cats were able to switch to less frequent dosing without losing the benefits of the treatment, and they experienced fewer side effects like vomiting and diarrhea when given the medication less often. This approach not only maintained their skin health but also made the treatment safer for them.
People also search for: cat skin allergies treatment · ciclosporin for cats side effects · cat vomiting after medication
Abstract
Objectives This study was designed to evaluate the efficacy and safety of reducing ciclosporin (CsA) dosing frequency from daily to every other day (EOD) or twice a week (TW) according to clinical response in cats with hypersensitivity dermatitis (HD) and treated with CsA. Methods One hundred and ninety-one cats with HD were given 7 mg/kg CsA daily for at least 4 weeks. Depending on clinical response, the dosing frequency was tapered from daily to EOD over the next 4 weeks and further to TW for an additional 4 weeks. Safety was evaluated through physical examinations, clinical pathology and the monitoring of adverse events (AEs). Results The majority of cats were able to have their dose of CsA tapered to either EOD (15.5%) or TW (62.9%) according to the clinical response. Observed AEs were most frequently mild and self-limiting vomiting and diarrhea. A higher percentage of AEs occurred with daily administration (73%) compared with other dosing regimens (27%). Conclusions and relevance Following 4 weeks of daily dosing at 7 mg/kg, CsA may be tapered to EOD or TW while maintaining the desired therapeutic response in cats with HD. Additionally, CsA appears to be well tolerated with fewer AEs at EOD or TW dosing. Establishing the lowest effective dosing frequency of CsA improves the drug's safety profile.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/26316515/