Peer-reviewed veterinary case report
Once-daily carbimazole controls hyperthyroidism in cats safely
By Frénais, R et al.·Published in The Journal of small animal practice·2009·Intervet/Schering-Plough Animal Health, France·View original on PubMed →
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Original publication title: Clinical efficacy and safety of a once-daily formulation of carbimazole in cats with hyperthyroidism.
- Species:
- cat
Plain-English summary
A group of 44 cats with hyperthyroidism (a condition where the thyroid gland is overactive) were treated with a new once-daily medication called carbimazole. After just 10 days, most cats showed significant improvement, with their thyroid hormone levels dropping from an average of 118 nmol/l to 33 nmol/l. By the end of the study, the cats continued to do well, and their symptoms improved or resolved within three weeks. While some cats experienced mild side effects, the treatment was generally well tolerated, making it a promising option for managing hyperthyroidism in cats.
People also search for: cat hyperthyroidism treatment · carbimazole for cats · symptoms of hyperthyroidism in cats
Abstract
OBJECTIVE: Evaluation of efficacy and safety of a novel controlled-release formulation of carbimazole in feline hyperthyroidism. METHODS: A multicentre, self-controlled study in 44 client-owned cats with history and clinical signs of hyperthyroidism, and total thyroxine concentration greater than or equal to 50 nmol/l. Treatment was started at 15 mg once daily, response assessed after 10 days, and 3, 5, 8, 26 and 53 weeks and dose adjusted as required. RESULTS: The median dose of carbimazole was 10 mg (range 10 to 15 mg) and 15 mg (5 to 25 mg) once daily after 3 and 53 weeks, respectively. Median total thyroxine concentration dropped significantly from 118 nmol/l (50 to 320 nmol/l) at presentation to 33 nmol/l (n=40) after 10 days, 31 nmol/l (n=34) at 3 weeks and 21 nmol/l (n=18) at 53 weeks. Clinical signs improved or resolved in almost all cats within three weeks after starting treatment. Twenty-one adverse reactions possibly (20) or probably (1) related to treatment were reported. During treatment, increased blood urea nitrogen concentration was observed in 25 per cent of the cats, eosinophilia in 20 per cent and lymphopenia in 16 per cent, while liver enzymes tended to improve. CLINICAL SIGNIFICANCE: Once daily administration of controlled-release carbimazole tablets was effective and had expected tolerance in hyperthyroid cats during short- and long-term treatment.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/19796309/