Peer-reviewed veterinary case report
Cefovecin injection treats bacterial skin infections in dogs safely
By Stegemann, M R et al.·Published in The Journal of small animal practice·2007·Pfizer Animal Health, United Kingdom·View original on PubMed →
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Original publication title: Clinical efficacy and safety of cefovecin in the treatment of canine pyoderma and wound infections.
- Species:
- dog
Plain-English summary
A group of dogs with bacterial skin infections, including pyoderma (a type of skin infection) and wounds, were treated with either cefovecin, an injectable antibiotic given every two weeks, or amoxicillin/clavulanic acid, an oral antibiotic taken twice daily. After treatment, cefovecin was found to be just as effective as the oral medication, with up to 96.9% of dogs showing improvement compared to 92.5% with the oral option. This means that cefovecin could be a great choice for pet owners since it eliminates the risk of missed doses that can happen with oral medications.
People also search for: dog skin infection treatment · cefovecin for dogs · pyoderma in dogs antibiotics
Abstract
OBJECTIVES: To determine the efficacy and safety of cefovecin in the treatment of bacterial skin infections in dogs. METHOD: Dogs with superficial or deep pyoderma or wounds/abscesses were enrolled in three separate studies. Dogs (354) were randomised to treatment and received either cefovecin administered by subcutaneous injection at 14 day intervals, as clinically necessary, or amoxicillin/clavulanic acid as oral tablets twice daily for 14 days. Courses of treatment were repeated at 14 day intervals up to a total of four courses. Clinicians responsible for assessing lesions were masked to treatment allocation. Only animals where the presence of a pretreatment bacterial pathogen was confirmed were included in the analysis of efficacy. Cases were evaluated for clinical efficacy at 28 days after initiation of the final course of treatment. Clinical efficacy was assessed by scoring the clinical signs typical of skin infections. RESULTS: Cefovecin demonstrated statistical non-inferiority compared with amoxicillin/clavulanic acid for all three clinical diagnoses; for cefovecin, up to 96.9 per cent efficacy was observed versus 92.5 per cent for amoxicillin/clavulanic acid. CLINICAL SIGNIFICANCE: Cefovecin was shown to be as effective as amoxicillin/clavulanic acid administered orally in the treatment of bacterial skin infections in dogs. Cefovecin offers the additional benefit of eliminating owner non-compliance.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/17559523/