Clinical Efficacy of Bleomycin in Canine Papillomatosis: Case Report of Two Sibling Puppies

Abstract

Aim: The objective was to assess the clinical efficacy of anti-tumoral bleomycin on canine papillomatosis (CP) in two male Pug breed sibling puppies. Material and Methods: Two 8 month-old, male sibling puppies were presented with multiple warts in the lip and chin. A suspected diagnosis of CP was established through only clinical examination with appearance of typical cauliflower-like warts. Bleomycin was subcutaneously administered to both siblings on a weekly by 0.5 IU/kg dosage. Results: At week 6, one of the siblings exhibited complete regression of oral lesions, whereas the other sibling achieved complete healing by week 9. The warts persistently show complete resolution, with no new lesions. No adverse effects were observed, verified through weekly blood count and physical examination during and post-treatment. Conclusion: Subcutaneous administration of bleomycin at weekly at a dose of 0.5 IU/kg contributed to the regression of oral lesions and improved clinical outcomes in dogs, suggesting potential efficiency in the treatment of CP.