Peer-reviewed veterinary case report
Effectiveness of PMPDAP drug in treating cats with feline
By Hartmann, Anja D et al.·Published in Journal of Feline Medicine and Surgery·2012·Clinic for Small Animal Medicine, Ludwig Maximilian University, Munich, Germany, Germany·View original on Crossref →
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Original publication title: Clinical efficacy of the acyclic nucleoside phosphonate 9-(2-phosphonylmethoxypropyl)-2,6-diaminopurine (PMPDAP) in the treatment of feline immunodeficiency virus-infected cats
- Species:
- cat
Plain-English summary
Twenty cats with feline immunodeficiency virus (FIV) were treated with a new antiviral medication called PMPDAP to see if it could help improve their health. The cats received the treatment twice a week for six weeks, and while there were no major differences in health compared to those receiving a placebo, some cats on PMPDAP showed slight improvements in their overall condition. However, there were some side effects related to blood health in the cats receiving the treatment. Overall, PMPDAP might be a potential option for FIV-infected cats, but veterinarians should be aware of the possible side effects.
People also search for: cat FIV treatment options · feline immunodeficiency virus symptoms · PMPDAP side effects in cats
Abstract
In in vitro studies, the acyclic nucleoside phosphonate 9-(2-phosphonylmethoxypropyl)-2,6-diaminopurine (PMPDAP) inhibited the replication of feline immunodeficiency virus (FIV). No information about its clinical efficacy is available so far. The aim of this prospective placebo-controlled, double-blinded study was to evaluate the antiviral efficacy of PMPDAP in cats naturally infected with FIV. Twenty cats were randomly assigned to two treatment groups receiving either PMPDAP (25 mg/kg) or placebo twice per week subcutaneously for 6 weeks. The general health status (Karnofsky’s score), clinical signs, laboratory, immunological, and surrogate parameters were evaluated. No significant differences were found between PMPDAP- and placebo-treated cats, although cats treated with PMPDAP showed a tendency for improvement in their Karnofsky’s score and clinical signs. Haematological side effects were noted in the PMPDAP-treated cats. Thus, PMPDAP may be an option in treating cats if it becomes available for veterinarians, but side effects have been monitored.
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Search related cases →Original publication on Crossref: https://doi.org/10.1177/1098612x11431040