Clinical Efficacy of Vascular Sealant in Promoting Rapid Recovery After Total Thyroidectomy for Thyroid Cancer.

Abstract

Objective To explicitly evaluate the clinical value of vascular sealant in enhancing early recovery following total thyroidectomy for thyroid cancer, with a specific focus on reducing perioperative complications, such as tissue fluid exudation, wound oozing, and lymph leakage. Methods A retrospective clinical study was conducted, involving 162 patients with thyroid cancer who were recruited at Tianjin First Central Hospital from January 2023 to December 2024. The cohort consisted of 62 men and 100 women, aged 20-78 years. Based on the method of wound management during surgery, patients were divided into the vascular sealant group (observation group, n=82) and the traditional wound management group (control group, n=80). Both groups underwent total thyroidectomy combined with bilateral central neck lymph node dissection. General clinical indicators such as operation time and intraoperative blood loss were recorded. The drainage volume on postoperative days 1 and day 2, total neck drainage during the perioperative period, and the duration of drain placement were compared between the two groups. Blood tests were conducted preoperative and on postoperative day 3 to assess white blood cell count, neutrophil count, C-reactive protein (CRP), and procalcitonin (PCT) levels. Perioperative complications were analyzed. Statistical analysis was performed using non-parametric tests for independent samples, chi-square tests, and other appropriate methods to evaluate the indices. Results On postoperative days 1 and day 2, the drainage volume, total neck drainage during the perioperative period, and the duration of drain placement in the observation group were significantly lower than those in the control group (all P<0.05). There were no significant differences in the preoperative white blood cell count, neutrophil count, CRP, and PCT levels between the two groups (all P>0.05). On postoperative day 3, the levels of these indicators were significantly lower in the observation group than in the control group (all <i>P<</i>0.05). Compared to their preoperative baseline, both groups showed significant increases in these indicators on postoperative day 3 (all P<0.01). The incidence of wound oozing (8, 9.8%) and lymph leakage (0, 0%) in the observation group was significantly lower than that in the control group ((17 (21.2%), 5 (5.0%)) (P<0.05).There was no significant difference in the risk of postoperative fever between the two groups (P>0.05). Conclusion Vascular sealant can effectively reduce tissue fluid exudation in the surgical area, decrease the risk of wound oozing and lymph leakage, and has significant advantages in promoting rapid postoperative recovery in patients undergoing total thyroidectomy for thyroid cancer.